Serious question. I have friends who use Ketamine recreationally, they tell me about an experience they sometimes have called the K hole, this sounds very strange and also very frightening. With this therapy is it likely people could experience this K hole affect? What implications does this have for people who have depression with depersonalisation and feel suicidal because of this disassociative feeling.
It’s low risk because it’s basically microdosed, similar to how other psychedelics are being studied right now. There are intravenous and intranasal options. It had legitimate medical use for mental health and it’s mechanism of action had nothing to do with being high. It’s extremely safe.
It’s being studied as a rapid acting suicide prevention therapy in traumatic military scenarios.
Ketamine is also a miracle for chronic pain management and a safe alternative to opioids and other risky treatment.
Source: was prescribed dat shit
Curious why is this still not in clinical use for depression? I understand the psychoactive potential of it but couldn't the argument be said true about opioids and amphetamines based drugs. If it's ill risks wouldn't anything have risks? OTC even. I don't understand
I spoke with someone who uses it for a brain tumor & he said ketamine made things seem wet & round.
I didn't see the paper specifically referenced in this article; but a newer paper was referenced which was released Feb 15, 2018. As I understand it was big deal as it outlined a possible mechanism for ketamine treatment of depression.
[Ketamine blocks bursting in lateral habenula to rapidly relieve depression \(Yang et al., 2018](https://www.nature.com/articles/nature25509
As I recall, the dose for this sort of treatment is *much* lower than was is used for recreational use. In this context it does not cause the same high, euphoria, and hallucinogenic effects.
Ketamine is an NMDAR antagonis, in this context it inhibits bursting activity in the lateral habenula (LHb). The LHb has been shows to be reward-negative, and neurons here fire in response to no reward, unpleasant events, routed from the [globus pallidus](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638585/
). Firing in the LHb has been shown to drive despair behavior and anhedonia. The ketamine blocks this effect. (Yang et al., 2018)
but have they tried not keeping people in a constant state of stress ? or is it cheaper with drugs ?