We're filmmakers working on an AI doc that features developments in the self-driving car industry. Ask us anything!
Human stem cell treatment cures alcoholism in rats. Rats that had previously consumed the human equivalent of over one bottle of vodka every day for up to 17 weeks under free choice conditions drank 90% less after being injected with the stem cells.
Great Pacific Garbage Patch is 16 times bigger than previously thought
People on antidepressant medication tend to also report experiencing emotional bluntness, a condition known as alexithymia, according to a preliminary study published in the journal Experimental and Clinical Psychopharmacology.
Biophysicists have imaged the moment a photon sparks the first energy conversion steps of photosynthesis.
Published this week in the International Journal of Obesity, the study suggests that parents who underestimate the sugar content of everyday foods and beverages commonly included in children’s diets are exposing their children to an increased risk of obesity or overweight.
More than one in 10 people who have never used class A drugs may have traces of cocaine or heroin on their fingertips, forensic scientists say. The scientists believe the participants became contaminated from banknotes, tables and other surfaces, as reported in the journal Clinical Chemistry.
Switching from unhealthy to healthier diet lowers depressive symptoms more than social support sessions
New Study Details "Death By Bee Acupuncture Therapy" after woman dies following two years of treatment. The procedure has been touted by Goop founder Gwyneth Paltrow, Kate Middleton, and others.
In field tests, a new water-harvesting device successfully pulled water from the desert air in Tempe, Arizona. The new technology could allow humans to survive in some of the most inhospitable regions on Earth.
Carbon nanotubes found to induce mesothelioma in mice at a similar rate to asbestos fibers.
Caloric restriction results in less oxidative damage and slowed down ageing
A new DNA analysis of the 'Atacama alien' skeleton reveals the genetic mutations that likely gave it its extraterrestrial appearance.
Genome Sequencing Adds 5 New Neanderthals to the Human Family Tree - "Having the genomes of these younger Neanderthals increases the amount of Neanderthal DNA that can be identified in present-day people."
Earwigs have wings that fold in ways that should be mathematically impossible, according to origami theory. The common pests have a rubbery polymer that lets them fold up their wings into tiny packages.
Medical expansion has improved health – with one exception: Increased spending on health care and increases in specialized care were both associated with longer life expectancy and less mortality, but growing drug industry linked to worse health in 30 countries.
A single intravenous infusion of ketamine led to a rapid decrease in suicidal ideations. Within a day, about 55% of individuals who received ketamine no longer had suicidal ideations compared to 20% who received placebo. This reduction in suicidal ideations lasted for at least 7 days.
Being in the hospital leads to a 20% drop in future earnings on average for adults 50-59, even if they have medical insurance
Toddlers learn nothing from YouTube videos. New study finds that two-year-olds enjoy the commercials more than the videos (and seem engaged with musical clips) but do not learn anything from YouTube.
Squids have a tougher time hunting these days, and it's because of climate change. High carbon dioxide levels affect how they go after prey, researchers found. It "could have far?reaching consequences in marine ecosystems due to the ecological importance of cephalopods in the marine food web."
Breast Implants Could Cause An Unusual Cancer
EPFL scientists have identified a mechanism that confers resistance against a common therapy for lymphoma. They propose an alternative treatment that targets lymphoma signaling at its root, and show that it can be effective in a broader group of patients. The study is published in the journal Blood.
Living abroad can clarify your sense of self. They found living abroad increases "self-concept clarity," the extent to which individuals' beliefs about themselves are clearly and confidently defined and consistent and stable over time.
Finding food is a necessary survival skill, but so is avoiding pain. Research using mice showed that being hungry activates a neural pathway that inhibits the perception of and response to chronic pain. The findings offer up new targets for treating pain.
3,4-Methylenedioxymethamphetamine (MDMA) for Psychiatric Treatment
Video of mating deep-sea anglerfish stuns biologists
A bat no bigger than a kiwi fruit logs distances of up to 100 kilometres on nightly round trips to its feeding grounds — the longest commute ever recorded for a nectar-feeding bat.
Where the Solar system meets the solar neighbourhood: patterns in the distribution of radiants of observed hyperbolic minor bodies. New evidence for Scholz's star
False-positive results released by direct-to-consumer genetic tests highlight the importance of clinical confirmation testing for appropriate patient care
Read with them, watch with them. Toddlers that co-view with an engaged parent learn more words from videos than those that watch alone.
Using diamond, scientists build first continuous room-temperature solid-state maser - the microwave version of lasers. Possible applications include medical imaging, airport security scanners, improved bomb detection, and quantum computers.
Rethinking the treatment of chronic fatigue syndrome—a reanalysis and evaluation of findings from a recent major trial of graded exercise and CBT | BMC Psychology
The Effort Paradox: Prominent models indicate that effort is costly, and that we avoid it. A new series of studies show that this is only half the story. Humans and non-human animals alike tend to associate effort with reward and will sometimes select activities because they require effort
How deep brain stimulation silenced cravings
Physicists create a Kagome metal which unique quantum properties at room temperature
The first known interstellar asteroid, 'Oumuamua (Hawaiian for "scout"), was likely ejected from a binary star system. By modeling how efficient various systems are at ejecting comets and asteroids, researchers showed 36% of binaries (the most common type of star system) eject primarily asteroids.
Biomimetic Artificial Organelles Implanted into Living Zebrafish Embryos made Functional In Vivo
New research on Plasmodium gametocytogenesis could provide a path for slowing the rate of malaria transmission
LaCroix (and other carbonated beverages) can lead to obesity.
Older adults may be more prone to false memories - Researchers have discovered that as people age, they may be more likely to rely on a type of memory, called schematic memory, that helps them remember the gist of an event, but not necessarily the details.
Wounds in the fetus can heal without scarring, a fact that has prompted scientists to design new biomaterials based on the properties of fetal skin. Now, a new type of nanofiber has been shown to heal wounds in mice faster and with less scarring than untreated wounds.
163 Astro_nauts_mum Early days yet. But very interesting.
85 SirT6 I had to do some digging, but it appears that the sensitivity of the test was 92% (i.e. it accurately identified people with ASD 92% of the time) and the specificity was 84% (i.e. it correctly identified people without ASD 84% of the time). Apply this to a real-world scenario: ASD occurs about 1 in 100 children. If you screen 100 children with this test, it will find 16 with ASD. But only one has ASD. The test will identify the one child correctly 92% of the time. Unlikely to be good enough as is to have much clinical utility. You also have to wonder how the experimental design impacts these numbers. For example, how much of the ASD group's metabolome was impacted by ASD meds? I'd also be curious to know more about the severity of ASD in the children in the study. Since the press article was pretty light on details, here is the [link to the research article]( if anyone is interested. **Abstract** *Background* Clinical chemistry tests for autism spectrum disorder (ASD) are currently unavailable. The aim of this study was to explore the diagnostic utility of proteotoxic biomarkers in plasma and urine, plasma protein glycation, oxidation, and nitration adducts, and related glycated, oxidized, and nitrated amino acids (free adducts), for the clinical diagnosis of ASD. *Methods* Thirty-eight children with ASD (29 male, 9 female; age 7.6 ± 2.0 years) and 31 age-matched healthy controls (23 males, 8 females; 8.6 ± 2.0 years) were recruited for this study. Plasma protein glycation, oxidation, and nitration adducts and amino acid metabolome in plasma and urine were determined by stable isotopic dilution analysis liquid chromatography-tandem mass spectrometry. Machine learning methods were then employed to explore and optimize combinations of analyte data for ASD diagnosis. *Results* We found that children with ASD had increased advanced glycation endproducts (AGEs), Nε-carboxymethyl-lysine (CML) and Nω-carboxymethylarginine (CMA), and increased oxidation damage marker, dityrosine (DT), in plasma protein, with respect to healthy controls. We also found that children with ASD had increased CMA free adduct in plasma ultrafiltrate and increased urinary excretion of oxidation free adducts, alpha-aminoadipic semialdehyde and glutamic semialdehyde. From study of renal handling of amino acids, we found that children with ASD had decreased renal clearance of arginine and CMA with respect to healthy controls. Algorithms to discriminate between ASD and healthy controls gave strong diagnostic performance with features: plasma protein AGEs—CML, CMA—and 3-deoxyglucosone-derived hydroimidazolone, and oxidative damage marker, DT. The sensitivity, specificity, and receiver operating characteristic area-under-the-curve were 92%, 84%, and 0.94, respectively. *Conclusions* Changes in plasma AGEs were likely indicative of dysfunctional metabolism of dicarbonyl metabolite precursors of AGEs, glyoxal and 3-deoxyglucosone. DT is formed enzymatically by dual oxidase (DUOX); selective increase of DT as an oxidative damage marker implicates increased DUOX activity in ASD possibly linked to impaired gut mucosal immunity. Decreased renal clearance of arginine and CMA in ASD is indicative of increased arginine transporter activity which may be a surrogate marker of disturbance of neuronal availability of amino acids. Data driven combination of these biomarkers perturbed by proteotoxic stress, plasma protein AGEs and DT, gave diagnostic algorithms of high sensitivity and specificity for ASD.
27 OliverSparrow Posted elsewhere, so here's what I have already said: [Here is a somewhat (!) more technical explanation]( Tthe researchers are aware, paediatric medicine has been looking at reactive oxygen species damage for decades - [review here]( Amongst the relevant molecules is indeed dityrosine. The researchers say: > [Other workers] found a link between ASD and damage to proteins in blood plasma by oxidation and glycation – processes where reactive oxygen species (ROS) and sugar molecules spontaneously modify proteins. What seems to be happening is that the body both relies upon oxygen and is damaged by it, and by molecules formed from it. Children who have poor control systems to manage this conflict suffer neural damage. This shows up as, amongst other things, autism spectrum disorder. (ROS are also implicated in neuro-degeneration in older people.) What this means, unhappily, is that whilst the relationship may give a pointer to at least some sources of ASD, there is unlikely to be a cure - the damage having been done when the symptoms appear. Children with high levels of ROS and markers of them can, perhaps, be put on an anti-oxidant regime, although what that would look like in practice and how successful it would be is unclear.
32 norieeega Who knows, maybe one day they will find a vaccine* against autism and heads will explode. *) I know, I know...
7 Shadowbanned24601 That link to AGEs is interesting... They tend to pop up in some degenerative diseases such as Alzheimer's too. And interestingly (well for me, I'm doing a PhD on it now), they are present at a relatively high level (compared to their presence in other foods) in infant formula. There might be a link there. Then again, might not. But worth investigating.
3 Scythe42 Heard on BBC this morning that the sample size was 38 children. They really shouldn't be making any claims off of this study.
1 Nebucadneza You dont know what to do with us autists now and now you want to stamp even more ? Soon autism is the new neurotypical