Copying my comment from the r/sciences post (where you can also see some of the data - something that is hard to capture in these press release type write-ups):
> The full article, *Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study* can be found [here](https://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.2018.17060720?download=true
> My thoughts: while a promising result, the lack of durability combined with the non-trivial safety profile makes it far from a slam dunk.
> This drug currently has Breakthrough Therapy Designation from the FDA for multiple psychiatric indications and is currently being evaluated in a pivotal Phase 3 study for Major Depressive Disorder. I’ll be excited to see the final results! We definitely need more tools in our psychiatric arsenal and this is probably the best test of the ketamine hypothesis (the idea that it is something of a wunder-drug for mental disorders).